SoupMan,
A lot of good suggestions have been posted here. I agree with Ryan’s suggestion of changing the axel ratio and upgrade to a Positraction differential. This alone could make a day and night difference. I am not aware of a 3.55:1 ratio for a GM 10 bolt; you may have to choose between a 3.42:1 or a 3.73:1. You mentioned the turbo 350 is already built for high HP/torque, so you could add the 200-4R at a later date. Just make sure the transmission you install is built to withstand your ultimate power goal, or you end up paying more in the long run. If you do much highway driving you will want an overdrive transmission.
As nas t eh mentioned you may be going down a Rabbit hole with one thing leading to another. Stock Pontiac connecting rods being a weak point. Probably OK for 400 horsepower, pushing it past that is asking a lot. Are you planning on installing sub-frame connectors to reinforce the chassis? Drive shaft and yoke upgrades from 1310 to 1350 u-joints? Too wild of a cam will sacrifice street drivability and reduce vacuum, you may have to install a hydro-boost for your power brakes. I would install a high capacity road race oil pan to avoid oil starvation during hard acceleration and cornering.
FYI for comparison, last year I replaced the stock low performance 301 in my 1980 TA with a 461 built by Butler Performance. I purchased it from another TAC member who had it built but he never installed it.
It has the following parts; XX-481988 400CI block, Lunati roller lifters, Comp custom grind billet roller cam, Scorpion roller lifters, Canton Road Race oil pan, Melling 80 PSI oil pump, Powerbond/Dayco harmonic balancer, Edelbrock 87cc D-port heads, Lunati valve springs, Chromemoly pushrods, Edlebrock Performer RPM intake, Ram Air Restorations 2.5” exhaust manifolds, Ross forged piston’s, Eagle H beam forged rods, Eagle 4340 forged crank, FAST EZ-EFI 2.0, FAST dual sync distributor and many many more parts. Engine was built, blueprinted, balanced and dyno tested by Butler at 488.7 HP at 5,000 RPM and 580.0 foot pounds at 3900 RPM. This motor has a mild cam and runs without problems on 93 octane pump gas. I do not know if the heads were ported or not. These numbers are less than the numbers you were looking for but not that far off.
While crankshaft dyno numbers are nice I think chassis RWHP is more valuable and will give you a better idea what your car will do. My car has a stock 1974 SD exhaust system and only a 2.41:1 axel ratio. I don’t plan to race it. Running the stock P225 70R -15 tires I have terrible traction problems. But still manage to get 4.4 second 0- 60 times with my performance computer (for what it’s worth).
Although I enjoy the power and torque, my car is used for cruising. For me it was important to have a normally aspirated Pontiac engine in my car. But if I wanted a 600 horsepower street monster with the best bang for the buck I would follow ryeguy2006a (Ryan) and do a super charged LS engine. The power, reliability, drivability and cost is hard to beat.
One last suggestion. You can certainly get a lot of power out of a Pontiac if you are willing to invest the time and money. I would suggest purchasing the book Max-Performance Pontiac V-8's, written by Rocky Rotella, ISBN 978-1-61325-474-5. It's filled with lots of valuable information.